The uncertainty in yesterday’s practice report has become a definite problem: Christian Mahogany and Blake Miller are out tonight, with hip and knee injuries respectively. Cornerback D.J. Reed is questionable with a foot injury; Juice Scruggs returned to full participation and has no game designation. Lions’ final report, September 16
Detroit arrives after a 31–30 overtime win over New Orleans, secured when the Saints failed a two-point attempt. Buffalo’s new Highmark Stadium gets its first regular-season visitors with both teams 1–0. The protection changes make Detroit’s early-down efficiency worth watching: falling behind the chains would give the replacement line a much less forgiving evening.
Kickoff: 8:15 p.m. ET, Prime Video with a US subscription. Official viewing guide
BETTING — PASS. Dimers’ forecast, updated 9:45 p.m. ET yesterday, gives Buffalo 68.1%. Its listed −213 moneyline requires about 68.05% just to break even—effectively no margin even before model uncertainty. That listing is not a verified executable FanDuel or DraftKings quote. The spread forecast is 50–50 at 5.5, and the total lacks enough supporting probability detail for a recommendation. Forecast and listed markets